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Unlike PURINETHOL (mercaptopurine) and IMURANŽ (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. The following information includes only the average doses of allopurinol. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Allopurinol will not relieve a gout attack that has already started.

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