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5 or 1 milligram of tesofensine was double that of weight loss seen with the currently available diet drugs Acomplia (rimonabant) or Meridia (sibutramine), the researchers said. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients.

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